CJC-1295

What is CJC-1295

CJC-1295 is a synthetic GHRH (growth hormone-releasing hormone) analog composed of 30 amino acids. The first 29 amino acids of GHRH constitute the active segment, which is provided in the form of the synthetic peptide Sermorelin. Sermorelin is further modified to extend its half-life to 30 minutes. This is known as CJC 1295. CJC-1295 is further modified by adding a DAC (Drug-Affinity Complex). The DAC binds to a blood protein called albumin, extending its half-life to 8 days. This is known as CJC 1295 + DAC. CJC 1295 can also be formulated without DAC to mimic the more normal physiological GH peaks occurring nightly. The longer half-life achieved by DAC binding to albumin means injections are only required once or twice weekly. However, the long half-life and relatively constant blood levels provide continuous stimulation for GH release from the pituitary via the GHRH receptor, which is not physiologically normal. This can reduce GH pulse amplitude, leading to diminished GH tissue stimulation. When one encounters the term “CJC 1295 without DAC,” it actually refers to MOD GRF 1-29. This tetra-substituted peptide is a modified form of the original GRF 1-29 peptide, commonly known as Semorelin. Due to the extremely short half-life of native GRF 1-29, chemists modified the peptide to provide longer bioactivity, thereby reducing metabolic clearance.

Benefits of CJC-1295

The primary use of CJC-1295 is to provide increased GH levels, which also leads to elevated IGF-1 levels. These increases can aid in fat reduction and, in some cases, muscle growth.

Promotes Muscle Growth

CJC-1295 stimulates growth hormone secretion, promoting protein synthesis and muscle growth. Its long-acting properties (half-life of 5-8 days) sustain pituitary release of growth hormone, enhancing muscle-building effects.

Accelerated Fat Breakdown

Increased growth hormone secretion promotes lipolysis, converting stored fat into energy while suppressing appetite to aid in body fat reduction. This mechanism makes it highly effective for fat loss.

Boosts Metabolic Rate

CJC-1295 elevates thyroid hormone (T3/T4) levels, further accelerating metabolism for more efficient fat loss.

Improves Sleep Quality

By promoting deep sleep, it aids physical recovery and maintains physiological functions, benefiting skin and overall health.

Enhances Immune Function

Regulating pituitary function boosts immunity, supporting the body’s defense against infections and inflammation.

CJC-1295 Dosage

CJC 1295 without DAC should be injected 1-3 times daily at 100mcg-200mcg per dose. A superior approach is using CJC 1295 with DAC, allowing athletes to inject only twice weekly at 2mg per dose. Additionally, daily GHRP injections may be incorporated. This provides smaller but more frequent growth hormone pulses. When using long-acting CJC1295, a three-month “hormone break” should be taken every three to six months to allow the pituitary gland to “recover,” considered the safest usage method.

CJC-1295 Side Effects

Nerve compression pain (e.g., carpal tunnel syndrome), injection site reactions (irritation, erythema, induration, pain, itching), headaches, diarrhea, vasodilation (flushing, fever, transient hypotension), nausea, abdominal pain, water retention, tingling, numbness, reduced insulin sensitivity, fatigue, drowsiness, agitation or excitement.