Sermorelin

What is Sermorelin and Its Mechanism of Action

Sermorelin acetate (also known as INN/Geref/Gerel), also referred to as GHRH (1-29), is a peptide analog of growth hormone-releasing hormone (GHRH). It serves as a diagnostic agent for evaluating growth hormone (GH) secretion and is used to diagnose growth hormone deficiency. It is a 29-amino acid polypeptide representing the 1-29 fragment of endogenous human GHRH, considered the shortest fully functional fragment of GHRH.
Sermorelin essentially mimics the hypothalamic peptide GHRH. It acts directly on the pituitary gland, stimulating the ability of somatocyte cells to produce and secrete GH. Sermorelin can influence the synergistic effects of hormonal signals affecting the GH axis. Growth hormone secretion from the anterior pituitary is regulated by ghrelin, somatostatin, and growth hormone-releasing factors. The rhythmic secretion of growth hormone, governed by the positive and negative regulation of ghrelin and somatostatin, creates a circadian growth hormone rhythm. Growth hormone, required for signaling to target cells, most significantly increases IGF-1 synthesis in the liver and peripheral tissues.

Sermorelin Fitness Benefits

Sermorelin has been observed to elevate blood hGH levels. Its benefits stem from this hGH elevation. Moreover, the increase in hGH levels is endogenous, resulting in a more moderate physiological response.
Increased muscle mass;
Reduced fat;
Improved overall physical well-being, including sleep quality, mental state, and general energy levels.

Sermorelin Dosage

The optimal dosage of Sermorelin is 0.2mg-0.5mg administered 1-3 times daily via subcutaneous or intramuscular injection.
Optimal timing: 15 minutes before meals, post-workout, and before bedtime.

Common Sermorelin Side Effects

Injection site reactions are most frequent (irritation, itching, redness, swelling), typically resolving spontaneously. Other rare side effects include:
· Difficulty swallowing
· Dizziness
· Facial/neck flushing
· Nausea
Seek immediate medical attention for severe adverse reactions.