In recent years, GLP-1 receptor agonists (GLP-1RAs) have shown remarkable efficacy in weight loss. It is often claimed that these drugs not only produce excellent weight loss results but also primarily reduce visceral adipose tissue (VAT) rather than subcutaneous adipose tissue (SAT). If this is indeed the case, what are the underlying biological mechanisms? This […]
Obesity, as a “blue ocean” in the field of chronic diseases, is driving intense drug R&D activity. A recent review published in Pharmaceuticals focuses on the limitations of existing incretin-based weight-loss drugs, optimizations in next-generation formulations, multi-target peptides, novel non-incretin targets, muscle-preserving strategies, and comparisons of clinical pipelines, systematically reviewing progress in obesity drug R&D
Obesity Reviews recently published a systematic review conducted by an international, multidisciplinary team of experts. The review was jointly authored by experts in endocrinology, obstetrics and gynecology, pharmacy, midwifery, and nutrition from multiple countries, and focused on the risks and benefits of GLP 1/GIP-class drugs among women of childbearing age (18–45 years) throughout the entire cycle—from
Today, we’ll introduce a powerhouse among peptides—one that’s versatile enough for both formal occasions and everyday use: CJC-1295. First, it’s important to understand that, when it comes to boosting endogenous growth hormone levels, there are two types of peptides that can achieve this effect: the first is growth hormone-releasing hormone (GHRH), and the second is
On June 18, GPNi organized a special event at the ISSN 2026 conference: the recording and live streaming of the “Peptides” online seminar. The level of interest in this webinar, to some extent, underscored the immense popularity of the topic “Peptides.” In the lead-up to the event, participants from various countries and regions—including the United
On the “niche watch list” of neuropeptide research, DSIP (δ-sleep-inducing peptide, CAS 62568-57-4) is a classic example of a substance whose name doesn’t quite live up to its reputation—in 1977, a Swiss team isolated this 9-amino acid peptide from rabbit cerebral venous blood. While its name is anchored in “sleep induction,” half a century later,
What exactly is cagrilintide? Cagrilintide is a long-acting amylin analog developed by Novo Nordisk. Amylin, also known as “islet amyloid polypeptide,” is normally secreted by pancreatic beta cells alongside insulin, but for a long time it has been the “forgotten supporting actor” in weight-loss treatments. Like GLP-1, Cagrilintide is administered via a once-weekly subcutaneous injection.
Tirzepatide. Not only does it effectively manage type 2 diabetes, but it has also demonstrated “game-changing” potential in the field of weight loss. Did you know? The reason this once-weekly injection provides long-lasting effects lies in a sophisticated design that allows it to “travel” through the human body. Today, we’ll take you through the entire
Slowing down aging has always been a topic of great concern to people; ancient emperors even went so far as to expend enormous material and human resources to sail the seas in search of elixirs of immortality. To explore the mechanisms of aging, scientists have proposed a series of hypotheses, including the oxygen free radical
Very effective! I’d say it’s an excellent weight-loss medication. Retatrutide, with its three targets, might be even better, but I’ve had great results with Tirzepatide.As a muscle-bound guy who’s been strength training for 12 years, this is the best miracle drug out there.For an endomorph who loves strength training, fat loss is actually a very
